Description

Buy Vasoactive Intestinal Peptide at PeptideLabCo: Your Trusted Source for High-Purity Research Peptides

Vasoactive intestinal peptide (VIP) underpins critical research in immunology, neurology, and cardiovascular science—but securing reliably pure VIP can delay experiments and compromise data integrity. PeptideLabCo solves this challenge by offering ≥ 98 % pure, HPLC-tested VIP with full documentation, rapid global shipping, and rigorous “for research use only” compliance. In this guide, you will discover:

1. Fundamental VIP biology and receptor mechanisms
2. Advantages of sourcing VIP through PeptideLabCo
3. Applications of VIP nasal spray in CIRS research
4. Broad research benefits across inflammation, neuroprotection, and gut health
5. Step-by-step ordering, handling, and compliance procedures
6. VIP’s role in Chronic Inflammatory Response Syndrome
7. Safety considerations and best practices for scholarly investigation

What Is Vasoactive Intestinal Peptide (VIP) and How Does It Function?

Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide and hormone that binds to G-protein-coupled receptors to promote vasodilation, bronchodilation, immunomodulation, and neuroprotection. This receptor-mediated mechanism elevates intracellular cAMP, enhancing smooth muscle relaxation and regulating cytokine release in immune cells. For researchers, understanding VIP’s multi-system functions lays the groundwork for experimental design and targeted applications.

What are the key biological functions of VIP?

Vasoactive Intestinal Peptide orchestrates several physiological processes through diverse cellular targets:

• Vasodilation: Relaxes vascular smooth muscle to regulate blood flow
• Bronchodilation: Eases airway constriction via bronchial smooth muscle relaxation
• Immunomodulation: Modifies dendritic cell maturation and T-cell cytokine profiles
• Neuroprotection: Supports neuronal survival, reduces oxidative stress, and promotes neurogenesis

VIP’s Role in Immune Modulation

Vasoactive Intestinal Peptide has been shown to exert anti-inflammatory effects by inhibiting pro-inflammatory cytokines and enhancing regulatory T-cell activity, making it a versatile tool for studying immune pathways. These mechanisms are key to understanding VIP’s utility in models of autoimmune inflammation and biotoxin-induced responses.

Delgado, M., et al., Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease (2023)

This research supports the article’s claims about VIP’s anti-inflammatory properties and its potential in treating inflammatory diseases.

Together, these functions frame Vasoactive Intestinal Peptide as a versatile tool for studying vascular, respiratory, immune, and neurological pathways. Exploring receptor binding details provides deeper insight into these roles.

How does VIP interact with VPAC1, VPAC2, and PAC1 receptors?

Receptor	Coupled G-Protein	Downstream Effect	Tissue Distribution
VPAC1	Gs	↑ cAMP, vasodilation	Vascular endothelium, immune cells
VPAC2	Gs	↑ cAMP, bronchodilation	Lung bronchial smooth muscle, brain
PAC1	Gs/Gq	↑ cAMP & ↑ IP3, neuroprotection	Central and peripheral neurons

This receptor specificity underlies VIP’s ability to differentially regulate cardiovascular tone, airway caliber, and neuronal resilience. Understanding these interactions guides experimental dosing and receptor-targeted assays.

Vasoactive Intestinal Peptide Receptor Interactions and Signaling

Vasoactive Intestinal Peptide interacts with VPAC1, VPAC2, and PAC1 receptors, triggering distinct signaling cascades that regulate cardiovascular tone, airway caliber, and neuronal resilience. Understanding these interactions is crucial for experimental design and receptor-targeted assays.

Fathi, M., Signal Transduction by VIP and PACAP Receptors (2022)

This research provides a detailed explanation of the signaling pathways activated by VIP receptors, which is relevant to the article’s discussion of VIP’s mechanisms of action.

What physiological effects does VIP have in research?

VIP’s multi-system modulation supports a range of experimental endpoints:

1. Vasodilation assays measuring arterial relaxation
2. Bronchoconstriction models evaluating airway responsiveness
3. Cytokine profiles in inflammatory cell cultures
4. Neuroprotection studies assessing neuronal survival under stress

These applications exploit VIP’s receptor-driven signaling to dissect vascular, respiratory, immune, and neurological processes—each further detailed in specialized research protocols.

Why Should Researchers Buy Vasoactive Intestinal Peptide from PeptideLabCo?

Choosing a peptide supplier affects reproducibility, compliance, and data quality. PeptideLabCo integrates advanced synthesis, stringent quality controls, and dedicated support to ensure VIP meets or exceeds research-grade standards.

What purity standards and quality controls does PeptideLabCo ensure?

Test Method	Attribute	Threshold/Result
HPLC	Peptide purity	≥ 98 %
Mass spectrometry	Molecular mass match	Within ± 0.1 Da
Amino acid analysis	Sequence confirmation	100 % correct sequence
Endotoxin assay	Bacterial contamination	< 0.1 EU/mg

Each batch is accompanied by a detailed Certificate of Analysis (CoA) documenting methods, results, CAS numbers, and PubChem CID identifiers. This transparency promotes trust and experimental rigor.

How does PeptideLabCo guarantee reliable shipping and customer service?

• Worldwide shipping in cryo-insulated packaging
• Real-time tracking with cold-chain monitoring
• Responsive technical support via email and phone
• Customized documentation for import/export compliance

These services minimize transit delays and ensure peptides arrive with full integrity, so experimental timelines remain uninterrupted.

What legal and ethical considerations apply to buying VIP as a research chemical?

1. Maintain Institutional Biosafety Committee (IBC) approval
2. Follow Material Safety Data Sheet (MSDS) handling guidelines
3. Observe local regulations for peptide importation
4. Dispose of waste under hazardous substance protocols

Adhering to these guidelines protects personnel, ensures legal compliance, and upholds ethical research standards. Next, we explore a specialized VIP format: nasal spray in CIRS studies.

How Is VIP Nasal Spray Used in Research and What Are Its Benefits?

VIP nasal spray delivers the peptide directly to the respiratory mucosa, enhancing bioavailability and targeting airway-immune interfaces. This format supports investigations into inhalation-based modulation of immune and inflammatory pathways.

What distinguishes VIP nasal spray from other VIP forms?

• Enhanced mucosal absorption for rapid onset
• Lower systemic degradation compared to injection
• Non-invasive administration enabling repeated dosing
• Adjustable dosing volumes for precise concentration control

These attributes facilitate respiratory research models and reduce peptide waste, advancing studies of airway inflammation and neuroimmunomodulation.

How is VIP nasal spray applied in Chronic Inflammatory Response Syndrome (CIRS) research?

1. Is administered at defined intervals (e.g., twice daily)
2. Targets local immune cells to reduce mucosal inflammation
3. Modulates cytokine release in biotoxin-induced inflammatory pathways

VIP in Chronic Inflammatory Response Syndrome (CIRS) Research

In CIRS models, VIP nasal spray is administered to reduce mucosal inflammation and modulate cytokine release in biotoxin-induced inflammatory pathways. This approach supports investigation of VIP’s role in reversing biotoxin-driven immune dysregulation.

Shoemaker, R., Intranasal VIP safely restores volume to multiple grey matter nuclei in patients with CIRS (2017)

This research supports the article’s claims about the use of VIP in treating CIRS and its effects on the body.

What are the differences between therapeutic and research uses of VIP nasal spray?

• Exclude excipients intended for human use
• Provide clear “for research use only” labeling
• Include granular purity documentation for assay reproducibility

Understanding these distinctions ensures correct regulatory handling and preserves the integrity of preclinical and clinical translational studies.

What Are the Research Applications and Benefits of Vasoactive Intestinal Peptide?

VIP’s pleiotropic actions make it a versatile tool across immunology, neurology, gastroenterology, and cardiovascular research. Each benefit derives from specific receptor-mediated pathways and offers unique experimental insights.

How does VIP support inflammation reduction and immune system regulation?

• Inhibiting pro-inflammatory cytokines (e.g., TNF-α, IL-6)
• Enhancing regulatory T-cell (Treg) activity
• Downregulating antigen presentation in dendritic cells

These mechanisms underlie VIP’s utility in models of autoimmune inflammation, sepsis, and biotoxin-induced responses, enabling researchers to dissect immune homeostasis and tolerance.

What neuroprotective effects of VIP have been observed in studies?

VIP promotes neuronal survival through:

1. Anti-apoptotic signaling via PAC1 receptor activation
2. Upregulation of neurotrophic factors like BDNF
3. Attenuation of glutamate-induced excitotoxicity

Neuroprotective Effects of VIP

Vasoactive Intestinal Peptide promotes neuronal survival through anti-apoptotic signaling, upregulation of neurotrophic factors, and attenuation of glutamate-induced excitotoxicity. Neuroscience studies leverage these effects to explore neurodegenerative disease models.

Passemard, S., et al., VIP-induced Neuroprotection of the Developing Brain (2011)

This research supports the article’s claims about the neuroprotective effects of VIP and its potential in treating neurodegenerative diseases.

Neuroscience studies leverage these effects to explore neurodegenerative disease models, brain injury recovery, and synaptic plasticity, with Vasoactive Intestinal Peptide serving as both probe and potential therapeutic lead.

How does VIP influence gut health and cardiovascular function in research?

• In the gut, VIP enhances epithelial barrier integrity and modulates peristalsis
• In the heart and vessels, VIP-induced vasodilation improves perfusion

These roles support studies on irritable bowel syndrome, cardiomyopathy models, and host-microbiome interactions, highlighting Vasoactive Intestinal Peptide cross-system investigative value.

How Can Researchers Purchase and Handle Vasoactive Intestinal Peptide at PeptideLabCo?

Ensuring proper procurement and handling of research peptides is essential for experimental success. PeptideLabCo’s streamlined process and detailed guidance empower investigators to integrate Vasoactive Intestinal Peptide seamlessly into protocols.

What is the ordering process for research-grade VIP at PeptideLabCo?

1. Submit a purchase requisition via PeptideLabCo’s secure portal
2. Receive order confirmation with CoA and shipping schedule
3. Arrange payment and regulatory documentation for export/import

What storage and handling procedures ensure VIP stability?

• Long-term storage at –20 °C in lyophilized form
• Short-term reconstituted storage at 4 °C for up to 48 hours
• Protection from repeated freeze-thaw cycles by aliquoting
• Use of sterile, low-binding tubes to maintain peptide integrity

Following these protocols preserves bioactivity and experimental consistency. Next, we detail documentation that PeptideLabCo supplies.

How does PeptideLabCo provide product information and purity documentation?

• Certificate of Analysis with HPLC chromatogram
• CAS numbers (37221-79-7, 40077-57-4) and PubChem CID (44567960)
• Detailed batch records and peptide synthesis data
• Material Safety Data Sheet outlining handling precautions

These comprehensive records support publication-quality data and regulatory audits, reinforcing research credibility.

What Is Chronic Inflammatory Response Syndrome (CIRS) and How Does VIP Research Support It?

Chronic Inflammatory Response Syndrome (CIRS) is a complex condition triggered by persistent exposure to biotoxins, characterized by systemic inflammation, cognitive impairment, and dysregulated immune responses. VIP research offers promising avenues for understanding and mitigating these effects.

What causes CIRS and what are its main symptoms?

• Dysregulated cytokine profiles and chronic inflammation
• Cognitive deficits such as brain fog and memory loss
• Respiratory symptoms including airway inflammation
• Fatigue, muscle aches, and dysautonomia

Defining CIRS pathology guides application of Vasoactive Intestinal Peptide immunomodulatory properties to restore homeostasis.

How does Vasoactive Intestinal Peptide modulate immune responses in CIRS research?

1. Suppresses overactive pro-inflammatory responses
2. Promotes Treg induction to rebalance immune tolerance
3. Enhances mucosal barrier function in respiratory and gastrointestinal tracts

These mechanisms support Vasoactive Intestinal Peptide as a research probe and potential adjunctive therapy in biotoxin-related chronic inflammation.

What scientific evidence supports VIP’s role in CIRS treatment research?

• Laboratory studies demonstrating VIP’s reduction of LPS-induced cytokines
• Animal models showing improved cognitive function after VIP administration
• Early clinical observations of symptom improvement in mold-exposed patients

This body of evidence positions Vasoactive Intestinal Peptide as a focal point for novel CIRS investigations, paving the way for targeted immunotherapy research.

What Are the Potential Side Effects and Considerations When Using VIP in Research?

Any bioactive peptide study requires rigorous assessment of safety and reproducibility. Vasoactive Intestinal Peptide potent activity necessitates careful experimental design to balance efficacy and risk.

What side effects have been observed in VIP research studies?

• Transient hypotension at high intravenous doses
• Occasional tachycardia in airway administration models
• Minimal injection-site irritation with subcutaneous formulations

Understanding these responses informs dose selection and monitoring in preclinical protocols.

How should researchers assess risks when working with VIP?

1. Conducting dose-escalation pilot studies to identify safe ranges
2. Monitoring physiological parameters (blood pressure, heart rate)
3. Using appropriate personal protective equipment and biosafety cabinets
4. Complying with institutional animal care and human subject protocols

These measures ensure that VIP investigations proceed with maximum safety and data validity.

How does PeptideLabCo ensure safe and ethical use of VIP peptides?

• Including detailed handling instructions in the MSDS
• Offering technical consultations on peptide solubility and bioactivity
• Reinforcing “for research use only” labeling on all materials
• Maintaining ISO-certified manufacturing and quality systems

This commitment to safety and ethics fosters reliable outcomes and regulatory confidence.

Vasoactive Intestinal Peptide unique combination of vasodilatory, bronchodilatory, immunomodulatory, and neuroprotective functions makes it an indispensable tool for modern biomedical research. PeptideLabCo’s dedication to ≥ 98 % purity, comprehensive documentation, and specialized support transforms VIP procurement from a logistical hurdle into a seamless step in your experimental workflow. By applying proper receptor-targeted protocols, storage procedures, and ethical guidelines, investigators can leverage VIP to unlock new insights into inflammation, neurodegeneration, gut health, and CIRS. Discover how PeptideLabCo delivers the precision and reliability your research demands—explore our VIP offerings today.